7/5/2023 0 Comments Download reviews of gluco d![]() ![]() ![]() ![]() In hepatocytes, GLUT1 is associated with the bi-directional transport of glucose controlled by hormones, such as thyroid hormone. In vitro animal and clinical studies have shown that the primary pancreatic beta cell sensor is glucokinase and not GLUT1 or GLUT2 (Efrat et al. The function of glucose sensing has two components: (1) entry of glucose into the cell mediated by GLUTs and (2) metabolism of glucose through phosporylation by glucokinase. GLUT2 acts as a glucose sensor in beta cells of marine organisms, but human beta cells express mainly GLUT1. Class I facilitative glucose transportersĬlass I facilitative glucose transportors are represented by GLUT1 to GLUT4, among which GLUT2 is expressed mainly in beta cells of the pancreas, liver and kidney. ![]()
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